Gene name:
Tnfrsf10b (Dr5;Killer) ;
Protein name:
Tumor necrosis factor receptor superfamily member 10B ;
Alternative:
MK ;Death receptor 5 ;
CD:
CD262 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homotrimer. Can interact with TRADD and RIPK1.
Function:
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MEPPGPSTPT | ASAAARADHY | TPGLRPLPKR | RLLYSFALLL | AVLQAVFVPV |
100:
TANPAHNRPA | GLQRPEESPS | RGPCLAGQYL | SEGNCKPCRE | GIDYTSHSNH |
150:
SLDSCILCTV | CKEDKVVETR | CNITTNTVCR | CKPGTFEDKD | SPEICQSCSN |
200:
CTDGEEELTS | CTPRENRKCV | SKTAWASWHK | LGLWIGLLVP | VVLLIGALLV |
250:
WKTGAWRQWL | LCIKRGCERD | PESANSVHSS | LLDRQTSSTT | NDSNHNTEPG |
300:
KTQKTGKKLL | VPVNGNDSAD | DLKFIFEYCS | DIVPFDSWNR | LMRQLGLTDN |
350:
QIQMVKAETL | VTREALYQML | LKWRHQTGRS | ASINHLLDAL | EAVEERDAME |
381:
KIEDYAVKSG | RFTYQNAAAQ | PETGPGGSQC | V
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 10B
ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 10B
CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 10B
CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 10B
Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 10B
Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 10B
Monoclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 10B
Monoclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 10B
Protein for Mouse Tumor necrosis factor receptor superfamily member 10B
Protein for Mouse Tumor necrosis factor receptor superfamily member 10B
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Kidney .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
tissue :
Spleen .
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"The transcriptional landscape of the mammalian genome."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
strain :
NOD .
tissue :
Aorta .
tissue :
Embryo .
tissue :
Vein .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
tissue :
Eye .